李玉桑

出生年月：1972.12 民族：汉族

学历学位：医学博士 职称：教授

学科专业：病理学、药理学

电话：027-67842332

电子邮箱：liys2006@mail.scuec.edu.cn

研究方向包括：包括肝癌在内肿瘤形成的病理学机制及抗肿瘤民族药物的干预研究；皮肤损伤机制及民族药物干预。

1997年毕业于湖南中医学院（现更名湖南中医药大学）临床医疗专业；1999年3月赴日本国立广岛大学医学部留学，于2006年3月，获人体病理学专业博士（医学）学位；2006年4月至2009年3月日本国立广岛大学大学院医学部任博士研究员；2009年4月任中南民族大学副教授；2015年7月任中南民族大学教授。

多年来主要从事包括肝癌在内肿瘤发生、发展的病理学机制及抗肿瘤民族药物的研发工作，特别是重点研究银屑病、特应性皮炎等慢性疑难皮肤疾患的发病机制和民族药物的作用机制。

工作期间，主持或参与包括国家自然科学基金在内项目等十余项，并在NanomedicineNBM、Journal of Ethnopharmacology、Journal of Agricultural and Food Chemistry、International Journal of Nanomedicine、Biomedicine & Pharmacotherapy等国际或国内学术刊物上发表了70余篇研究论文，获国家发明专利21项，其中包括美白祛斑、气血双补、抑郁康复等10项专利技术已经完成了科技成果转化。

一、奖励

一等奖，论文题名“浸潤性微小乳頭癌的淋巴行性转移及血管新生因子的表达”；第13届日本乳腺癌学术总会，2005；

一等奖，论文题名“The reversed apical pattern of MUC1 expression is characteristics of invasive micropapillary carcinoma of the breast”；第8届日本乳腺癌学会优秀论文奖，2007

二、近五年代表性研究论文(#为共同第一作者；*为通讯作者)

1. Zhang Z, Ma SY, Yin X,Li YS*, Tang HB. Topical frankincense treatment for frostbite based on microcirculation improvements.Journal of Ethnopharmacology. 2025, 336:118728. doi: 10.1016/j.jep.2024.118728.

2. Yin X, Gu HW, Ning D, Li YS, Tang HB. Testosterone Exacerbates the Formation of Liver Cancer Induced by Environmental N-Nitrosamines Exposure: Potential Mechanisms and Implications for Human Health.OncoTargets and Therapy. 2024, 17: 395-409. doi: 10.2147/OTT.S456746.

3. Zhai SY, Gu HW, Wang C,Li YS*, Tang HB. Gynura procumbens and selected metabolites: Amelioration of depressive-like behaviors in mice and risperidone-induced hyperprolactinemia in rats.Biomed Pharmacother. 2024, 173: 116361. doi: 10.1016/j.biopha.2024.116361.

4. Yin X#,Li YS#, Ye SZ, Zhang T, Zhang YW, Xi Y, Tang HB. Promotion Effect of Coexposure to a High-Fat Diet and Nano-Diethylnitrosamine on the Progression of Fatty Liver Malignant Transformation into Liver Cancer.International Journal of Molecular Sciences. 2023, 24(18): 14162. doi: 10.3390/ijms241814162.

5. Meng SS, Gu HW, Zhang T,Li YS*, Tang HB. Gradual deterioration of fatty liver disease to liver cancer via inhibition of AMPK signaling pathways involved in energy-dependent disorders, cellular aging, and chronic inflammation.Frontiers in Oncology. 2023, 13: 1099624. doi: 10.3389/fonc.2023.1099624.

6. Yin X, Hong J, Tang HB, Liu M,Li YS*. Enhanced healing of oral chemical burn by inhibiting inflammatory factors with an oral administration of shengFu oil.Frontiers inPharmacology. 2022, 13: 913098. doi: 10.3389/fphar.2022.913098.

7. Wang C, Huang XL, Mu YM,Li YS*, He YM, Tang HB. Synergistic effects of trans-p-coumaric acid isolated from the ethanol extract of Gynura procumbens in promoting intestinal absorption of chlorogenic acid and reversing alcoholic fatty liver disease.Journal of Ethnopharmacology.2022, 295: 115407. doi: 10.1016/j.jep.2022.115407.

8. Zhang T, Gu HW, Gao JX,Li YS*, Tang HB. Ethanol supernatant extracts of Gynura procumbens could treat nanodiethylnitrosamine-induced mouse liver cancer by interfering with inflammatory factors for the tumor microenvironment.Journal of Ethnopharmacology. 2022, 285: 114917. doi: 10.1016/j.jep.2021.114917.

9.Li YS, Zhang J, Tian GH, Shang HC, Tang HB. Kirenol, darutoside and hesperidin contribute to the anti-inflammatory and analgesic activities of Siegesbeckia pubescens makino by inhibiting COX-2 expression and inflammatory cell infiltration.Journal of Ethnopharmacology. 2021, 268: 113547. doi: 10.1016/j.jep.2020.113547.

10. Hong J, Chen XZ, Peng YG, Zhang WK, Tang HB,Li YS*. Nanoparticle-Encapsulated Liushenwan Could Treat Nanodiethylnitrosamine-Induced Liver Cancer in Mice by Interfering With Multiple Critical Factors for the Tumor Microenvironment.Frontiers inPharmacology. 2020, 11: 1052. doi: 10.3389/fphar.2020.01052.

11. Zheng L, Li XY, Huang FZ, Zhang XT, Tang HB,Li YS*, Zhang WK, Li XJ, Tian GH. Effect of electroacupuncture on relieving central post-stroke pain by inhibiting autophagy in the hippocampus.Brain Research. 2020, 1733: 146680. DOI: 10.1016/j.brainres.2020.146680.

12. Qin QF, Li XJ,Li YS*, Zhang WK, Tian GH, Shang HC, Tang HB. AMPK-ERK/CARM1 signaling pathways affect autophagy of hepatic cells in samples of liver cancer patients.Frontiers in Oncology. 2019, 9: 1247. DOI: 10.3389/fonc.2019.01247.

13. Huang XL, Li XJ, Qin QF,Li YS*, Zhang WK, Tang HB. Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils fromGynura procumbens, a traditional medicine and a new and popular food material.Journal of Ethnopharmacology.2019, 239: 111916.DOI: 10.1016/j.jep.2019.111916.

14. Chen MT, Zhang WK, Liang WL,Li YS, Li XJ, Zhu LH, Tang HB. Controllable and extra-fast synthesis of bio-applicable silver nanoparticles withLycium Barbarum L.Materials Technology. 2019, DOI: 10.1080/10667857.2019.1603656

15. Li XJ, Huang FZ, Wan Y,Li YS,Zhang WK, Xi Y, Tian GH, Tang HB. Lipopolysaccharide stimulated the migration of NIH3T3 Cells through a positive feedback between β-catenin and COX-2.Frontiers in Pharmacology. 2018, 9: 1487.

16. Qin QF, Liu M, Tian GH, Chen J,Li YS*. Extract of the blood circulation-promoting recipe-84 can protect rat retinas by inhibiting the beta-catenin signaling pathway.International Journal of Molecular Sciences.2018, 19: 2712.

17. Chen XZ, Zhang WK, Tang HB, Li XJ, Tian GH, Shang HC,Li YS*. The ethanol supernatant extracts of Liushenwan could alleviate nanodiethylnitrosamine-induced liver cancer in mice.Canadian Journal of Gastroenterology and Hepatology. 2018, 2018: 6934809.

18. Zhang MT, Ye XX, Lan W, Yang YL, Wu T,Li YS*, Tang HB. Strategic combination of isocratic and gradient elution for simultaneous separation of polar compounds in traditional Chinese medicines by HPLC.Journal of Analytical Methods in Chemistry. 2018, 2018: 7569283.

三、近年主持或参与的国家自然科学基金项目

1.基于β-catenin/COX-2炎性环路探究外用生肤油促进糖尿病足病快速修复的效应机制，2021年国家自然科学基金面上项目；

2.平卧菊三七干预“β-catenin/COX-2”炎性环路的防治肝癌机制研究.2016年国家自然科学基金面上项目；

3.电针对CPSP大鼠星形胶质细胞介导的Wnt/β-catenin信号通路调控作用.2016年国家自然科学基金面上项目

4.六神丸干预“β-catenin与COX-2环路”的镇癌痛机制研究.2015年国家自然科学基金面上项目；

5.基于Wnt/β-catenin靶点的益气活血方抗糖尿病视网膜病变作用机制研究。2012年国家自然科学基金青年项目；

6. Wnt/β-catenin信号通路调控原发性肝癌发生的机制研究.2011年国家自然科学基金青年项目；

7.非神经细胞对背根神经节神经细胞内P物质释放的调控机制。2010年国家自然科学基金面上项目；